Christina Applegate has announced that she will no longer be a part of her sitcom Up All Night. The NBC show has been on hiatus for several months while undergoing some major creative tweaking including the departure of series creator Emily Spivey. Applegate announced in a statement, "It's been a great experience working on Up All Night, but the show has taken a different creative direction and I decided it was best for me to move on to other endeavors. Working with Lorne Michaels has been a dream come true and I am grateful he brought me into his TV family. I will miss the cast, producers and crew, and wish them the best always." The show is set to film five new episodes this month to finish up its second season and switch from the single-camera to a multi-cam format with a studio audience. Deadline.com is reporting that Lisa Kudrow is being eyed as a replacement though her producing partner Dan Bucatinsky took to Twitter to deny the rumor.